Incidence of Total Knee and Hip Replacement for Osteoarthritis in Relation to Circulating Sex Steroid Hormone Concentrations in Women
Sultana Monira Hussain, Flavia M Cicuttini, Robin J Bell, Penelope J Robinson, Susan R Davis, Graham G Giles, Stephen Graves, Roger L Milne, Yuanyuan Wang
Arthritis & Rheumatology | WILEY-BLACKWELL | Published : 2014
OBJECTIVE: The increased prevalence of osteoarthritis (OA) in postmenopausal women suggests that changes in either circulating sex steroid concentrations or the tissue response to sex steroids may have a role in the pathogenesis of OA. The aim of this study was to examine whether circulating sex steroid concentrations are associated with the incidence of total knee and total hip replacement for OA. METHODS: Study subjects (n = 2,621; all women) were recruited in 1990-1994 from the Melbourne Collaborative Cohort Study (MCCS). Circulating sex steroid concentrations were measured in blood samples obtained from the women at the time of recruitment. The incidence of total knee and total hip repla..View full abstract
Awarded by National Health and Medical Research Council of Australia
Supported by the National Health and Medical Research Council of Australia (program grant 209057, capacity building grant 251533, and enabling grant 396414). Infrastructure support was provided by Cancer Council Victoria. Recruitment of the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. Dr. Hussain is recipient of an Endeavour International Postgraduate Research Scholarship and Australian Postgraduate Award from the Australian government, and a Faculty Excellence Scholarship from Monash University.