Journal article

Lovastatin for the adjunctive treatment of schizophrenia: A preliminary randomized double-blind placebo-controlled trial

Ahmad Ghanizadeh, Zahra Rezaee, Sara Dehbozorgi, Michael Berk, Shahin Akhondzadeh



While statins target many of the pathways to neuroprogression in schizophrenia, the safety and efficacy of statins for treating schizophrenia has never been examined. This is an 8-week randomized double blind controlled clinical trial examining the efficacy and safety of adjunctive lovastatin (20 mg/day) treatment or placebo for people with schizophrenia. The baseline characteristics of the two groups were not different. Endpoint changes in Positive and Negative Syndrome Scale (PANSS) total and subscale scores did not differ between the two groups. However there was a significant difference between the doses of risperidone used in the two groups. The mean dose in the lovastatin and placebo g..

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University of Melbourne Researchers


Awarded by Shiraz University of Medical Sciences

Awarded by NHMRC

Funding Acknowledgements

This study was supported by a grant (no: 2715) from Shiraz University of Medical Sciences to Prof. Ahmad Ghanizadeh. This study was Dr. Rezaei's postgraduate thesis toward the Iranian Board of Psychiatry. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660.