Biological insights from 108 schizophrenia-associated genetic loci

S Ripke; BM Neale; A Corvin; JTR Walters; KH Farh; PA Holmans; P Lee; B Bulik-Sullivan; DA Collier; H Huang; TH Pers; I Agartz; E Agerbo; M Albus; M Alexander; F Amin; SA Bacanu; M Begemann; RA Belliveau; J Bene; SE Bergen; E Bevilacqua; TB Bigdeli; DW Black; R Bruggeman; NG Buccola; RL Buckner; W Byerley; W Cahn; G Cai; D Campion; RM Cantor; VJ Carr; N Carrera; SV Catts; KD Chambert; RCK Chan; RYL Chen; EYH Chen; W Cheng; EFC Cheung; SA Chong; CR Cloninger; D Cohen; N Cohen; P Cormican; N Craddock; JJ Crowley; D Curtis; M Davidson; KL Davis; F Degenhardt; J Del Favero; D Demontis; D Dikeos; T Dinan; S Djurovic; G Donohoe; E Drapeau; J Duan; F Dudbridge; N Durmishi; P Eichhammer; J Eriksson; V Escott-Price; L Essioux; AH Fanous; MS Farrell; J Frank; L Franke; R Freedman; NB Freimer; M Friedl; JI Friedman; M Fromer; G Genovese; L Georgieva; I Giegling; P Giusti-Rodríguez; S Godard; JI Goldstein; V Golimbet; S Gopal; J Gratten; L De Haan; C Hammer; ML Hamshere; M Hansen; T Hansen; V Haroutunian; AM Hartmann; FA Henskens; S Herms; JN Hirschhorn; P Hoffmann; A Hofman; MV Hollegaard; DM Hougaard; M Ikeda; I Joa

Journal article

Biological insights from 108 schizophrenia-associated genetic loci

S Ripke, BM Neale, A Corvin, JTR Walters, KH Farh, PA Holmans, P Lee, B Bulik-Sullivan, DA Collier, H Huang, TH Pers, I Agartz, E Agerbo, M Albus, M Alexander, F Amin, SA Bacanu, M Begemann, RA Belliveau, J Bene Show all

Nature | Published : 2014

DOI: 10.1038/nature13595

Abstract

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD..

View full abstract

University of Melbourne Researchers

Eric Yu Hai Chen Author

Christos Pantelis Author

Grants

Awarded by U.S. Department of Veterans Affairs

Funding Acknowledgements

Core funding for the Psychiatric Genomics Consortium is from the US National Institute of Mental Health (U01 MH094421). We thank T. Lehner (NIMH). The work of the contributing groups was supported by numerous grants from governmental and charitable bodies as well as philanthropic donation. Details are provided in the Supplementary Notes. Membership of the Wellcome Trust Case Control Consortium and of the Psychosis Endophenotype International Consortium are provided in the Supplementary Notes.