Journal article

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke, Benjamin M Neale, Aiden Corvin, James TR Walters, Kai-How Farh, Peter A Holmans, Phil Lee, Brendan Bulik-Sullivan, David A Collier, Hailiang Huang, Tune H Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A Bacanu, Martin Begemann, Richard A Belliveau, Judit Bene Show all

Nature | NATURE PUBLISHING GROUP | Published : 2014

Abstract

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD..

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University of Melbourne Researchers

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Awarded by US National Institute of Mental Health


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by Veterans Affairs


Awarded by Lundbeck Foundation


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Awarded by Chief Scientist Office


Funding Acknowledgements

Core funding for the Psychiatric Genomics Consortium is from the US National Institute of Mental Health (U01 MH094421). We thank T. Lehner (NIMH). The work of the contributing groups was supported by numerous grants from governmental and charitable bodies as well as philanthropic donation. Details are provided in the Supplementary Notes. Membership of the Wellcome Trust Case Control Consortium and of the Psychosis Endophenotype International Consortium are provided in the Supplementary Notes.