Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism
Maria M Docanto, Fangyuan Yang, Brid Callaghan, CheukMan C Au, Rahini Ragavan, Xuyi Wang, John B Furness, Zane B Andrews, Kristy A Brown
BREAST CANCER RESEARCH AND TREATMENT | SPRINGER | Published : 2014
Aromatase converts androgens into estrogens and its expression within adipose stromal cells (ASCs) is believed to be the major driver of estrogen-dependent cancers in older women. Ghrelin is a gut-hormone that is involved in the regulation of appetite and known to bind to and activate the cognate ghrelin receptor, GHSR1a. The unacylated form of ghrelin, des-acyl ghrelin, binds weakly to GHSR1a but has been shown to play an important role in regulating a number of physiological processes. The aim of this study was to determine the effect of ghrelin and des-acyl ghrelin on aromatase in primary human ASCs. Primary human ASCs were isolated from adipose tissue of women undergoing cosmetic surgery..View full abstract
Awarded by NHMRC (Australia)
Awarded by National Breast Cancer Foundation
This research was supported by NHMRC (Australia) Project Grant # GNT1005735 and by a grant from the National Breast Cancer Foundation (NC-14-011) to KAB, and by the Victorian Government Operational Infrastructure Support Program. KAB is supported by an NHMRC (Australia) Career Development Award GNT1007714. We thank Mr Seungmin Ham for his technical support.