2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas; Denis B Scanlon; Briony E Forbes; Irina Vetter; Richard J Lewis; James Gardiner; Frances Separovic; John D Wade; Mohammed A Hossain

Journal article

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas, Denis B Scanlon, Briony E Forbes, Irina Vetter, Richard J Lewis, James Gardiner, Frances Separovic, John D Wade, Mohammed A Hossain

Chemistry: A European Journal | WILEY-V C H VERLAG GMBH | Published : 2014

DOI: 10.1002/chem.201403574

University of Melbourne Researchers

Frances Separovic Author Chemistry

John Karas Author Chemistry

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

John Wade Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by NHMRC

Funding Acknowledgements

This research was partially funded by the NHMRC Project grants 1023321 and 1023078 to M. A. H. and J.D.W. and C.S.I.R.O. (Australia). We thank the following people: Feng Lin for amino acid analysis, Dr. Keiko Hojo for assistance with the racemization study, Dr. Julien Tailhades for his expertise in iso-acyl dipeptides, Assoc. Prof. Uta Wille and Dr. Catrin Goeschen for access to their photoreactor, and Assoc. Prof. Craig Hutton and Dr. Jade Cottam for access to their polarimeter. J.D.W. is an NHMRC (Australia) Principal Research Fellow. Research at the Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program.