The Incidence of Neovascular Subtypes in Newly Diagnosed Neovascular Age-Related Macular Degeneration
Jesse J Jung, Christine Y Chen, Sarah Mrejen, Roberto Gallego-Pinazo, Luna Xu, Marcela Marsiglia, Sucharita Boddu, K Bailey Freund
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2014
PURPOSE: To determine the frequency of neovascularization subtypes as determined by fluorescein angiography (FA) alone vs FA and optical coherence tomography (OCT) grading in age-related macular degeneration (AMD). DESIGN: Retrospective cohort. METHODS: participants: Newly diagnosed neovascular AMD patients who initiated intravitreal anti-vascular endothelial growth factor therapy by 1 physician from October 1, 2005 to December 1, 2012. interventions: Two independent graders classified the baseline lesions using FA alone and FA+OCT. main outcome measures: Analysis of the frequency of lesion subtypes by FA alone or FA+OCT and agreement between both classification systems was performed. RESULT..View full abstract
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST and the following were indicated: K.B.F.: consultant to Regeneron, Genentech, Bayer Health Care, and Heidelberg Engineering (honorarium for each); R.G.P.: consultant to Carl Zeiss Meditec, Bayer Health Care, and Novartis (honorarium for each); research support from Bayer Healthcare, Novartis, Heidelberg Engineering, Thea, Sensimed; D.T. (biostatistical consultant): consultant to Regeneron. This work was supported by a research grant from the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY, and The Macula Foundation Inc., New York, NY. The funding organizations had no role in the design or conduct of this research. Contributions of authors: design of the study (J.J.J., S.M., R.G.P., K.B.F.), conduct of the study (J.J.J., C.Y.C., S.M., R.G.P., L.X., M.M., S.B., K.B.F.), collection of the data (J.J.J., S.M., R.G.P., L.X., M.M., S.B.), management of the data (J.J.J., C.Y.C., S.M., S.G.P., L.X., M.M., S.B., K.B.F.), analysis of the data (J.J.J., C.Y.C., S.M., L.X., K.B.F.), interpretation of the data (J.J.J., C.Y.C., S.M., R.G.P., L.X., M.M., K.B.F.), preparation of the manuscript (J.J.J., C.Y.C.), review of the manuscript (J.J.J., C.Y.C., S.M., R.G.P., L.X., M.M., S.B., K.B.F.), and approval of the manuscript (J.J.J., C.Y.C., S.M., R.G.P., L.X., M.M., S.B., K.B.F.).