Activating BRAF and PIK3CA Mutations Cooperate to Promote Anaplastic Thyroid Carcinogenesis
Roch-Philippe Charles, Jillian Silva, Gioia Iezza, Wayne A Phillips, Martin McMahon
Molecular Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2014
UNLABELLED: Thyroid malignancies are the most common type of endocrine tumors. Of the various histologic subtypes, anaplastic thyroid carcinoma (ATC) represents a subset of all cases but is responsible for a significant proportion of thyroid cancer-related mortality. Indeed, ATC is regarded as one of the more aggressive and hard to treat forms of cancer. To date, there is a paucity of relevant model systems to critically evaluate how the signature genetic abnormalities detected in human ATC contribute to disease pathogenesis. Mutational activation of the BRAF protooncogene is detected in approximately 40% of papillary thyroid carcinoma (PTC) and in 25% of ATC. Moreover, in ATC, mutated BRAF ..View full abstract
Awarded by National Cancer Institute
Awarded by NATIONAL CANCER INSTITUTE
R.-P. Charles was supported by a Swiss National Science Foundation Fellowship, J. Silva was supported by Institutional Research and Academic Career Development Award (IRACDA), W. A. Phillips was supported by project grants from the National Health and Medical Research Council of Australia, and M. McMahon was supported by the National Cancer Institute (CA131261).