Journal article

Role of metal ions in the cognitive decline of Down syndrome

Nakisa Malakooti, Melanie A Pritchard, Paul A Adlard, David I Finkelstein

Frontiers in Aging Neuroscience | FRONTIERS MEDIA SA | Published : 2014

Abstract

Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer's disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid βpeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS.

Grants

Funding Acknowledgements

Nakisa Malakooti is supported by the NHMRC, Paul A. Adlard is supported by the NHMRC and ARC. In addition, the Florey Institute of Neuroscience and Mental health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.