Journal article

Interactions of metals and Apolipoprotein E in Alzheimer's disease

He Xu, David I Finkelstein, Paul A Adlard

Frontiers in Aging Neuroscience | FRONTIERS MEDIA SA | Published : 2014

Abstract

Alzheimer's disease (AD) is the most common form of dementia, which is characterized by the neuropathological accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs). Clinically, patients will endure a gradual erosion of memory and other higher order cognitive functions. Whilst the underlying etiology of the disease remains to be definitively identified, a body of work has developed over the last two decades demonstrating that AD plasma/serum and brain are characterized by a dyshomeostasis in a number of metal ions. Furthermore, these metals (such as zinc, copper and iron) play roles in the regulation of the levels of AD-related proteins, including the ..

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Grants

Funding Acknowledgements

Paul A. Adlard and David I. Finkelstein are supported by the NHMRC and ARC. In addition, the Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.