The role of chemokines in severe malaria: more than meets the eye
Lisa J Ioannidis, Catherine Q Nie, Diana S Hansen
Parasitology (Cambridge) | CAMBRIDGE UNIV PRESS | Published : 2014
Plasmodium falciparum malaria is responsible for over 250 million clinical cases every year worldwide. Severe malaria cases might present with a range of disease syndromes including acute respiratory distress, metabolic acidosis, hypoglycaemia, renal failure, anaemia, pulmonary oedema, cerebral malaria (CM) and placental malaria (PM) in pregnant women. Two main determinants of severe malaria have been identified: sequestration of parasitized red blood cells and strong pro-inflammatory responses. Increasing evidence from human studies and malaria infection animal models revealed the presence of host leucocytes at the site of parasite sequestration in brain blood vessels as well as placental t..View full abstract
Supported by the Australian Government National Health and Medical Research Council IRIISS and Project Grant 1031212.