Journal article

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

EE To, BRS Broughton, KS Hendricks, R Vlahos, S Selemidis

FREE RADICAL RESEARCH | TAYLOR & FRANCIS LTD | Published : 2014

Abstract

Influenza A virus infects resident alveolar macrophages in the respiratory tract resulting in Toll like receptor 7 (TLR7) activation that triggers an inflammatory response to resolve the infection. Macrophages are also major sources of reactive oxygen species (ROS) via the NOX2-containing NADPH oxidase. Although ROS are crucial for pathogen clearance, in response to influenza A virus, ROS are touted as being culprit mediators of the lung tissue injury. The aim of the present study was to determine whether influenza A virus infection and TLR7 activation of macrophages, results in alterations in their ROS production. Here we demonstrate using immunofluorescence that influenza A virus (Hong Kon..

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University of Melbourne Researchers