SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study
Marcia Regina Pizzo de Castro, Michael Maes, Roberta Losi Guembarovski, Carolina Batista Ariza, Edna Maria Vissoci Reiche, Heber Odebrecht Vargas, Mateus Medonca Vargas, Luiz Gustavo Piccoli de Melo, Seetal Dodd, Michael Berk, Maria Angelica Ehara Watanabe, Sandra Odebrecht Vargas Nunes
BMC Genetics | BMC | Published : 2014
BACKGROUND: The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current tobacco use disorder, diagnosed according to DSM IV criteria (n = 185), and never-smokers, diagnosed according to CDC criteria (n = 175), were recruited and received 52 weeks of combined pharmacotherapy and cognitive therapy. Successful smoking cessation was defined as exhaled carbon monoxide < 6 ppm. SLC6A4 gene STin2 VNTR polymorphism was assessed using a Multiplex-PCR-based met..View full abstract
Awarded by NHMRC
MB is supported by a NHMRC Senior Principal Research Fellowship 1059660.MM is supported by a CNPq (Conselho Nacional de Desenvolvimento Cientifico e Technologia) PVE fellowship and the Health Sciences Graduate Program fellowship, Londrina State University (UEL).This study was supported by Health Sciences Postgraduate Program at Londrina State University, Paran, Brazil (UEL) and Araucaria Foundation.