Journal article

T cell mediated immunity to influenza: mechanisms of viral control

Nicole L La Gruta, Stephen J Turner

TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2014

Abstract

Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality. Recent findings indicate that T cell immunity is key to limiting severity of disease arising from IAV infection, particularly in instances where antibody immunity is ineffective. As such, there is a need to understand better the mechanisms that mediate effective IAV-specific cellular immunity, especially given that T cell immunity must form an integral part of any vaccine designed to elicit crossreactive immunity against existing and new strains of influenza virus. Here, we review the current understanding of cellular immunity to IAV, highlighting recent findings that demonstrate important roles for..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

This work is supported by an Australian Research Council Future Fellowship (awarded to S.J.T.); a Sylvia and Charles Viertal Senior Research Fellowship (awarded to N.L.L.); Australian National Health and Medical Research Council (NHMRC) program grant 5671222 (awarded to S.J.T.) and NHMRC project grant AI1046333 (awarded to N.L.L.).