Journal article

Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease - FEBS anniversary prize lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw

TL Spires, AJ Hannan

FEBS JOURNAL | WILEY | Published : 2005

Abstract

Neurodegenerative disorders, such as Huntington's, Alzheimer's, and Parkinson's diseases, affect millions of people worldwide and currently there are few effective treatments and no cures for these diseases. Transgenic mice expressing human transgenes for huntingtin, amyloid precursor protein, and other genes associated with familial forms of neurodegenerative disease in humans provide remarkable tools for studying neurodegeneration because they mimic many of the pathological and behavioural features of the human conditions. One of the recurring themes revealed by these various transgenic models is that different diseases may share similar molecular and cellular mechanisms of pathogenesis. C..

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