TRPing Up the Genome: Tandem Repeat Polymorphisms as Dynamic Sources of Genetic Variability in Health and Disease
Anthony J Hannan
Discovery Medicine | DISCOVERY MEDICINE | Published : 2010
Repetitive DNA sequences constitute a large fraction of the genomes of humans and other animal species. Tandem repeats are a major class of repetitive DNA and the extent of their polymorphic distributions and functions within the human genome are only beginning to be explored. Tandem repeat polymorphisms (TRPs) provide a unique source of genomic variability and recent evidence suggests they can modulate a range of biological processes, in developing and mature organisms. Tandem repeats can change length during meiosis and mitosis, providing a dynamic source of genetic variation which may not only influence evolutionary processes, but also somatic cellular selection. Furthermore, recent evide..View full abstract
The NHMRC and a Pfizer Australia Research Fellowship have supported the author's research. I thank past and present members of the Hannan Laboratory for useful discussions.