Journal article

TRPing Up the Genome: Tandem Repeat Polymorphisms as Dynamic Sources of Genetic Variability in Health and Disease

Anthony J Hannan

Discovery Medicine | DISCOVERY MEDICINE | Published : 2010


Repetitive DNA sequences constitute a large fraction of the genomes of humans and other animal species. Tandem repeats are a major class of repetitive DNA and the extent of their polymorphic distributions and functions within the human genome are only beginning to be explored. Tandem repeat polymorphisms (TRPs) provide a unique source of genomic variability and recent evidence suggests they can modulate a range of biological processes, in developing and mature organisms. Tandem repeats can change length during meiosis and mitosis, providing a dynamic source of genetic variation which may not only influence evolutionary processes, but also somatic cellular selection. Furthermore, recent evide..

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