Journal article

Symptom onset in autosomal dominant Alzheimer disease A systematic review and meta-analysis

Davis C Ryman, Natalia Acosta-Baena, Paul S Aisen, Thomas Bird, Adrian Danek, Nick C Fox, Alison Goate, Peter Frommelt, Bernardino Ghetti, Jessica BS Langbaum, Francisco Lopera, Ralph Martins, Colin L Masters, Richard P Mayeux, Eric McDade, Sonia Moreno, Eric M Reiman, John M Ringman, Steve Salloway, Peter R Schofield Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014


OBJECTIVE: To identify factors influencing age at symptom onset and disease course in autosomal dominant Alzheimer disease (ADAD), and develop evidence-based criteria for predicting symptom onset in ADAD. METHODS: We have collected individual-level data on ages at symptom onset and death from 387 ADAD pedigrees, compiled from 137 peer-reviewed publications, the Dominantly Inherited Alzheimer Network (DIAN) database, and 2 large kindreds of Colombian (PSEN1 E280A) and Volga German (PSEN2 N141I) ancestry. Our combined dataset includes 3,275 individuals, of whom 1,307 were affected by ADAD with known age at symptom onset. We assessed the relative contributions of several factors in influencing ..

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Awarded by NIA

Awarded by J.O. and J.R. Wicking Trust

Awarded by NIH

Awarded by Colciencias and Universidad de Antioquia



Awarded by National Institute for Health Research

Funding Acknowledgements

The Dominantly Inherited Alzheimer Network (DIAN) is supported by NIA grant U19 AG032438 to J.C. Morris, and by the generous support of F. Simmons and O. Mohan and an anonymous foundation, in addition to DIAN site support from the German Center for Neurodegenerative Diseases (DZNE), the NIHR Queen Square Dementia Biomedical Research Unit, the DIAN Expanded Registry (, and J.O. and J.R. Wicking Trust grants 13026 and 20821. Work with the Volga German PSEN2 N141I kindred was supported by NIH grants AG 05136, AG 11762, AG 21544, and GM 46255 to T. Bird and by the Department of Veterans Affairs. Work with the Colombian PSEN1 E280A kindred was supported by grant 1115 545 31651 from Colciencias and Universidad de Antioquia to F. Lopera and by an anonymous foundation.