The Role of Oxidative Stress and Inflammation in Cardiovascular Aging
Junzhen Wu, Shijin Xia, Bill Kalionis, Wenbin Wan, Tao Sun
BioMed Research International | HINDAWI LTD | Published : 2014
Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade inflammation accompanying aging recapitulate age-related cardiovascular dysfunction, that is, left ventricular hypertrophy, fibrosis, and diastolic dysfunction in the heart as well as endothelial dysfunction, reduced vascular elasticity, and increased vascular stiffness. We describe the signaling involved ..View full abstract
Awarded by National Natural Science Foundation of China
This work was supported by National Natural Science Foundation of China (Grant no. 31171129).