Journal article

The Role of Oxidative Stress and Inflammation in Cardiovascular Aging

Junzhen Wu, Shijin Xia, Bill Kalionis, Wenbin Wan, Tao Sun

BioMed Research International | HINDAWI LTD | Published : 2014

Abstract

Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade inflammation accompanying aging recapitulate age-related cardiovascular dysfunction, that is, left ventricular hypertrophy, fibrosis, and diastolic dysfunction in the heart as well as endothelial dysfunction, reduced vascular elasticity, and increased vascular stiffness. We describe the signaling involved ..

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