Journal article

Glutamatergic Nonpyramidal Neurons From Neocortical Layer VI and Their Comparison With Pyramidal and Spiny Stellate Neurons

Sofija Andjelic, Thierry Gallopin, Bruno Cauli, Elisa L Hill, Lisa Roux, Sammy Badr, Emilie Hu, Gabor Tamas, Bertrand Lambolez

Journal of Neurophysiology | AMER PHYSIOLOGICAL SOC | Published : 2009

Abstract

The deeper part of neocortical layer VI is dominated by nonpyramidal neurons, which lack a prominent vertically ascending dendrite and predominantly establish corticocortical connections. These neurons were studied in rat neocortical slices using patch-clamp, single-cell reverse transcription-polymerase chain reaction, and biocytin labeling. The majority of these neurons expressed the vesicular glutamate transporter but not glutamic acid decarboxylase, suggesting that a high proportion of layer VI nonpyramidal neurons are glutamatergic. Indeed, they exhibited numerous dendritic spines and established asymmetrical synapses. Our sample of glutamatergic nonpyramidal neurons displayed a wide var..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Neurological Disorders and Stroke


Awarded by Hungarian Academy of Sciences National Office for Research and Technology


Awarded by Hungarian Scientific Research Fund


Awarded by Howard Hughes Medical Institute


Awarded by Human Frontier Science Program Young Investigator Award


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

S. Andjelic was the recipient of a Fondation pour la Recherche Me ~ dicale fellowship. G. Tama s was supported by European Young Investigator Awards; National Institute of Neurological Disorders and Stroke Grant NS-35915; Hungarian Academy of Sciences National Office for Research and Technology Grants KFKT-1-2006-009 and RET008/2004; Hungarian Scientific Research Fund Grants T049535 and TS049868; and Howard Hughes Medical Institute Grant 55005625. B. Cauli was supported by Human Frontier Science Program Young Investigator Award RGY0070.