Journal article
Glutamatergic Nonpyramidal Neurons From Neocortical Layer VI and Their Comparison With Pyramidal and Spiny Stellate Neurons
Sofija Andjelic, Thierry Gallopin, Bruno Cauli, Elisa L Hill, Lisa Roux, Sammy Badr, Emilie Hu, Gabor Tamas, Bertrand Lambolez
JOURNAL OF NEUROPHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2009
Abstract
The deeper part of neocortical layer VI is dominated by nonpyramidal neurons, which lack a prominent vertically ascending dendrite and predominantly establish corticocortical connections. These neurons were studied in rat neocortical slices using patch-clamp, single-cell reverse transcription-polymerase chain reaction, and biocytin labeling. The majority of these neurons expressed the vesicular glutamate transporter but not glutamic acid decarboxylase, suggesting that a high proportion of layer VI nonpyramidal neurons are glutamatergic. Indeed, they exhibited numerous dendritic spines and established asymmetrical synapses. Our sample of glutamatergic nonpyramidal neurons displayed a wide var..
View full abstractGrants
Awarded by National Institute of Neurological Disorders and Stroke
Awarded by Hungarian Academy of Sciences National Office for Research and Technology
Awarded by Hungarian Scientific Research Fund
Awarded by Howard Hughes Medical Institute
Awarded by Human Frontier Science Program Young Investigator Award
Funding Acknowledgements
S. Andjelic was the recipient of a Fondation pour la Recherche Me ~ dicale fellowship. G. Tama s was supported by European Young Investigator Awards; National Institute of Neurological Disorders and Stroke Grant NS-35915; Hungarian Academy of Sciences National Office for Research and Technology Grants KFKT-1-2006-009 and RET008/2004; Hungarian Scientific Research Fund Grants T049535 and TS049868; and Howard Hughes Medical Institute Grant 55005625. B. Cauli was supported by Human Frontier Science Program Young Investigator Award RGY0070.