Journal article

Disruption of brain white matter microstructure in women with anorexia nervosa

Esther Via, Andrew Zalesky, Isabel Sanchez, Laura Forcano, Ben J Harrison, Jesus Pujol, Fernando Fernandez-Aranda, Jose Manuel Menchon, Carles Soriano-Mas, Narcis Cardoner, Alex Fornito

Journal of Psychiatry and Neuroscience | CMA-CANADIAN MEDICAL ASSOC | Published : 2014

Abstract

BACKGROUND: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its pathophysiology, implying a dysfunction of connected neural circuits. Despite these findings, the role of white matter in anorexia nervosa has been rarely assessed. In this study, we used diffusion tensor imaging (DTI) to characterize alterations of white matter microstructure in a clinically homogeneous sample of patients with anorexia nervosa. METHODS: Women with anorexia nervosa (restricting subtype) and healthy controls underwent brain DTI. We used tract-based spatial statistics to compare fractional anisotropy (FA) and mean diffusivity (MD) maps between the g..

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Grants

Awarded by Carlos III Health Institute


Awarded by National Health and Medical Research Council of Australia (NHMRC) Biomedical Career Development Award


Awarded by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award


Awarded by Miguel Servet contract from the Carlos III Health Institute


Funding Acknowledgements

This study was supported in part by the Carlos III Health Institute (PI081549, PI 11210). A. Zalesky is supported by a National Health and Medical Research Council of Australia (NHMRC) Biomedical Career Development Award (I.D. 1047648). B. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509). C. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). A. Fornito is supported by a CR Roper Fellowship (University of Melbourne). CIBERSAM and CIBEROBN are both initiatives of ISCIII. The authors thank all of the study subjects as well as the staff from the Department of Psychiatry of Hospital Universitari de Bellvitge. We also thank E. Martinez-Heras, MSc (IDIBAPS, Barcelona) for his contribution in earlier phases of this study.