Journal article

Risk of Newly Detected Infections and Cervical Abnormalities in Women Seropositive for Naturally Acquired Human Papillomavirus Type 16/18 Antibodies: Analysis of the Control Arm of PATRICIA

Xavier Castellsague, Paulo Naud, Song-Nan Chow, Cosette M Wheeler, Maria Julieta V Germar, Matti Lehtinen, Jorma Paavonen, Unnop Jaisamrarn, Suzanne M Garland, Jorge Salmeron, Dan Apter, Henry Kitchener, Julio C Teixeira, S Rachel Skinner, Genara Limson, Anne Szarewski, Barbara Romanowski, Fred Y Aoki, Tino F Schwarz, Willy AJ Poppe Show all

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2014

Abstract

BACKGROUND: We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). METHODS: Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). RESULTS: High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lo..

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