Journal article
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
J Grosse, H Heffron, K Burling, MA Hossain, AM Habib, GJ Rogers, P Richards, R Larder, D Rimmington, AA Adriaenssens, L Parton, J Powell, M Binda, WH Colledge, J Doran, Y Toyoda, JD Wade, S Aparicio, MBL Carlton, AP Coll Show all
Proceedings of the National Academy of Sciences of the United States of America | Published : 2014
Abstract
The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lacking the cognate receptor Rxfp4. Plasma Insl5 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding. We conclude that Insl5 is an orexigenic hormone released from ..
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Awarded by Medical Research Council
Funding Acknowledgements
F.M.G., F.R., G.J.R., P.R., S.O., and A.M. H. are funded by the Wellcome Trust (088357, 084210, and 095515). A.P.C., R.L., D.R., and S.O. are funded by Medical Research Council (MRC) Programme Grant G9824984, MRC Centre for Obesity and Related Metabolic Disease (MRC CORD) (G0600717), and subsequently MRC Metabolic Diseases Unit (4050281695) and the National Institute for Health Research Cambridge Biomedical Research Centre (CG50826). J.D.W. is a National Health and Medical Research Council of Australia Principal Research Fellow. Studies at the Florey Institute of Neuroscience and Mental Health were supported by the Victorian Government's Operational Infrastructure Support Program and the Australian Research Council Linkage Grant LP120100654.