The molecular regulation of Janus kinase (JAK) activation
Jeffrey J Babon, Isabelle S Lucet, James M Murphy, Nicos A Nicola, Leila N Varghese
Biochemical Journal | PORTLAND PRESS LTD | Published : 2014
The JAK (Janus kinase) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine kinase 2), was first described more than 20 years ago, but the complexities underlying their activation, regulation and pleiotropic signalling functions are still being explored. Here, we review the current knowledge of their physiological functions and the causative role of activating and inactivating JAK mutations in human diseases, including haemopoietic malignancies, immunodeficiency and inflammatory diseases. At the molecular level, recent studies have greatly advanced our knowledge of the structures and ..View full abstract
Awarded by NHMRC
Awarded by National Institutes of Health, U.S.A.
Awarded by NHMRC IRIISS grant
Awarded by NATIONAL CANCER INSTITUTE
The authors acknowledge fellowship support from the Australian Research Council (to J.J.B. and J.M.M.) and the NHMRC (National Health and Medical Research Council) (to N.A.N.), scholarship support from the Leukaemia Foundation and Australian Stem Cell Centre (to L.V.), grant support from the NHMRC [grant number 1011804] and the National Institutes of Health, U.S.A. [grant number CA22556], with additional support from the Victorian State Government Operational Infrastructure Scheme and NHMRC IRIISS grant [grant number 361646].