Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
Sean L McGee, Courtney Swinton, Shona Morrison, Vidhi Gaur, Duncan E Campbell, Sebastian B Jorgensen, Bruce E Kemp, Keith Baar, Gregory R Steinberg, M Hargreaves
The FASEB Journal | FEDERATION AMER SOC EXP BIOL | Published : 2014
The authors thank Frosa Katsis (St. Vincent's Institute, Fitzroy, VIC, Australia) for the generation of HDAC5 and ACC phospho-specific antibodies and Professor Doreen Cantrell (The University of Dundee, Dundee, UK) for the PKD plasmids. This study was supported by grants from the Australia National Health and Medical Research Council (NHMRC) to S. L. M., B. E. K., and G. R. S. S. L. M. is supported by the Diabetes Australia Research Trust Viertel Award and a Career Development Fellowship from the NHMRC. Author contributions: S. L. M. and M. H. conceived the research; S. L. M., C. S., S. M., V. G., D. E. C., and S.B.J. performed experiments and analyzed data; B. E. K., K. B., and G. R. S. provided technical expertise and reagents; S. L. M. wrote the paper; all authors edited the paper and approved the final version.