Journal article
Examination of risk factors for intellectual and academic outcomes following treatment for pediatric medulloblastoma
JE Schreiber, JG Gurney, SL Palmer, JK Bass, M Wang, S Chen, H Zhang, M Swain, ML Chapieski, MJ Bonner, DJ Mabbott, SJ Knight, CL Armstrong, R Boyle, A Gajjar
Neuro Oncology | Published : 2014
Abstract
Background The aim of this study was to prospectively examine the effects of hearing loss and posterior fossa syndrome (PFS), in addition to age at diagnosis and disease risk status, on change in intellectual and academic outcomes following diagnosis and treatment in a large sample of medulloblastoma patients. Methods Data from at least 2 cognitive and academic assessments were available from 165 patients (ages 3-21 years) treated with surgery, risk-adapted craniospinal irradiation, and 4 courses of chemotherapy with stem cell support. Patients underwent serial evaluation of cognitive and academic functioning from baseline up to 5 years post diagnosis. Results Serious hearing loss, PFS, youn..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported in part by the National Cancer Institute through a Cancer Center Support (CORE) grant (P30-CA21765), the Noyes Brain Tumor Foundation, Musicians Against Childhood Cancer (MACC), and by the American Lebanese Syrian Associated Charities (ALSAC).