Journal article

Design and characterization of sulfobetaine-containing terpolymer biomaterials

Daniel E Heath, Stuart L Cooper



A methacrylic terpolymer system with non-fouling interfacial properties was synthesized by the random copolymerization of hexyl methacrylate, methyl methacrylate and sulfobetaine methacrylate (a monomer bearing a zwitterionic pendant group). Polymers were synthesized from feeds containing 0-15 mol.% of the zwitterion-containing methacrylate. Proton nuclear magnetic resonance verified the incorporation of sulfobetaine methacrylate into the polymer structure. Water absorption studies illustrate that the hydrophilicity of the material increases with increasing zwitterion concentration. The biological properties of the polymer were probed by fibrinogen adsorption, human umbilical vein endothelia..

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University of Melbourne Researchers


Awarded by Ohio State University Nanoscale Science and Engineering Center (NSEC) (NSF)

Awarded by NIH Grant

Funding Acknowledgements

Funding for this research was supplied by The Ohio State University Nanoscale Science and Engineering Center (NSEC) (NSF Grant EEC-0425626) and NIH Grant RC2 AG036559. We would like to thank several individuals for their contribution to this work: Dr. Garland Fussell, who did the initial work with this polymer system; Dr. Douglas Kniss and Dr. Nicanor Moldovan, who allowed generous access to their cell culture facilities; Dr. Funminiyi Ajayi, for drawing the blood used in this work; and Dr. John Lannutti, for access to his electrospinning facility.