Journal article
Electrospun scaffold topography affects endothelial cell proliferation, metabolic activity, and morphology
Daniel E Heath, John J Lannutti, Stuart L Cooper
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | WILEY-BLACKWELL | Published : 2010
DOI: 10.1002/jbm.a.32802
Abstract
A family of methacrylic terpolymer biomaterials was electrospun into three-dimensional fibrous scaffolds. The glass transition temperature of the polymer correlates with the morphology of the resulting scaffold. Glassy materials produce scaffolds with discrete fibers and a high percent void space (84%) while the rubbery materials produced scaffolds with fused fibers and a much lower percent void space (18%). By electrospinning onto a rotating mandrel, aligned fiber scaffolds were fabricated, and it was shown that controlling the rotation speed of the collector allowed for control over the degree of fiber alignment. The electrospinning was shown to not degrade the number average molecular wei..
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Awarded by Ohio State University Nanoscale Science and Engineering Center (NSEC), NSF
Funding Acknowledgements
Contract grant sponsor: Ohio State University Nanoscale Science and Engineering Center (NSEC), NSF; contract grant number: EEC-0425626