Journal article

Design and characterization of PEGylated terpolymer biomaterials

Daniel E Heath, Stuart L Cooper

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | WILEY | Published : 2010

Abstract

A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0-25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81 degrees -68 degrees) and an increase in the equilibrium water absorption (0.7-237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 microg/cm(2) fibrinogen, 18,000 HUVECs/cm(2), and 3,000,000 platelets/cm(2) adsorbed or adhered on non-PEGylated ma..

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