Journal article

Interactions between endothelial cells and electrospun methacrylic terpolymer fibers for engineered vascular replacements

AN Veleva, DE Heath, JK Johnson, J Nam, C Patterson, JJ Lannutti, SL Cooper

Journal of Biomedical Materials Research Part A | WILEY | Published : 2009

Abstract

A compliant terpolymer made of hexylmethacrylate (HMA), methylmethacrylate (MMA), and methacrylic acid (MAA) intended for use in small diameter vascular graft applications has been developed. The mechanical properties and in vitro biostability of this terpolymer have been previously characterized. The goal of this investigation was to examine the interactions between endothelial cells and the new terpolymer and to evaluate endothelial cell function. Electrospinning was used to produce both oriented and random terpolymer fiber scaffolds. Smooth solution cast films and tissue culture polystyrene were used as negative and positive controls, respectively. Human blood outgrowth endothelial cells ..

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University of Melbourne Researchers