Studying Age-Related Macular Degeneration Using Animal Models
Erica L Fletcher, Andrew I Jobling, Ursula Greferath, Samuel A Mills, Michelle Waugh, Tracy Ho, Robb U de Iongh, Joanna A Phipps, Kirstan A Vessey
OPTOMETRY AND VISION SCIENCE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Over the recent years, there have been tremendous advances in our understanding of the genetic and environmental factors associated with the development of age-related macular degeneration (AMD). Examination of retinal changes in various animals has aided our understanding of the pathogenesis of the disease. Notably, mouse strains, carrying genetic anomalies similar to those affecting humans, have provided a foundation for understanding how various genetic risk factors affect retinal integrity. However, to date, no single mouse strain that develops all the features of AMD in a progressive age-related manner has been identified. In addition, a mutation present in some background strains has c..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (grant no. 1021918) and Retina Australia.