Journal article

Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential

Chiara Cristina Bortolasci, Michael Maes, Heber Odebrecht Vargas, Andre Souza-Nogueira, Estefania Gastaldello Moreira, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Decio Sabbatini Barbosa

Neuroscience Letters | ELSEVIER IRELAND LTD | Published : 2014


The measurement of the total radical trapping antioxidant potential (TRAP) is a general marker of peripheral blood antioxidant defenses. Paraoxonase 1 (PON1) is a potent antioxidant, which protects against lipid peroxidation. The study aimed to examine the relation between TRAP levels and PON1 activity, PON1 Q192R functional genotypes, smoking, interactions between PON1 genotypes and smoking, and mood disorders, while adjusting for effects of ethnicity, marital status, body mass index (BMI) and gender. The analyses were performed in 197 controls and 136 subjects with mood disorders. TRAP levels were significantly associated with higher plasma PON1 activity, the RR functional genotype, non sm..

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