Journal article

A comparison of open-loop and closed-loop stimulation strategies to control excitation of retinal ganglion cells

Tatiana Kameneva, Daniele Zarelli, Dragan Nesic, David B Grayden, Anthony N Burkitt, Hamish Meffin

Biomedical Signal Processing and Control | ELSEVIER SCI LTD | Published : 2014


Currently, open-loop stimulation strategies are prevalent in medical bionic devices. These strategies involve setting electrical stimulation that does not change in response to neural activity. We investigate through simulation the advantages of using a closed-loop strategy that sets stimulation level based on continuous measurement of the level of neural activity. We propose a model-based controller design to control activation of retinal neurons. To deal with the lack of controllability and observability of the whole system, we use Kalman decomposition and control only the controllable and observable part. We show that the closed-loop controller performs better than the open-loop controlle..

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Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by the Australian Research Council through the Discovery Early Career Researcher Award (DECRA) DE120102210. This research was supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology grant to Bionic Vision Australia. The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy and the Australian Research Council through the ICT Centre of Excellence program.