Severe Pandemic H1N1 2009 Infection Is Associated with Transient NK and T Deficiency and Aberrant CD8 Responses
Annette Fox, Nguyen Minh Hoa Le, Peter Horby, H Rogier van Doorn, Vu Trung Nguyen, Hong Ha Nguyen, Trung Cap Nguyen, Dinh Phu Vu, Minh Ha Nguyen, Nguyen Thi Ngoc Diep, Vu Thi Ngoc Bich, Tran Thi Kieu Huong, Walter R Taylor, Jeremy Farrar, Heiman Wertheim, Van Kinh Nguyen
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012
BACKGROUND: It is unclear why the severity of influenza varies in healthy adults or why the burden of severe influenza shifts to young adults when pandemic strains emerge. One possibility is that cross-protective T cell responses wane in this age group in the absence of recent infection. We therefore compared the acute cellular immune response in previously healthy adults with severe versus mild pandemic H1N1 infection. METHODS AND PRINCIPAL FINDINGS: 49 previously healthy adults admitted to the National Hospital of Tropical Diseases, Viet Nam with RT-PCR-confirmed 2009 H1N1 infection were prospectively enrolled. 39 recovered quickly whereas 10 developed severe symptoms requiring supplementa..View full abstract
Awarded by European Union
This work was funded by the Wellcome Trust of Great Britain and The South East Asian Infectious Diseases Clinical Research Network. AF was supported by the European Union FP7 project "European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE)'' (no. 223498). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the patients for agreeing to participate in the study. We thank the Ministry of Health of Viet Nam and the staff of the National Hospital of Tropical diseases for their continued support for our work and for their dedication to high quality research into infectious diseases in Viet Nam.