Acute Measles Encephalitis in Partially Vaccinated Adults
Annette Fox, Manh Hung Than, Heiman Wertheim, Nguyen Minh Hoa Le, Angela Vincent, Bethan Lang, Patrick Waters, Hong Ha Nguyen, Vu Trung Nguyen, Jeremy Farrar, Van Kinh Nguyen, Peter Horby
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: The pathogenesis of acute measles encephalitis (AME) is poorly understood. Treatment with immune-modulators is based on theories that post-infectious autoimmune responses cause demyelination. The clinical course and immunological parameters of AME were examined during an outbreak in Vietnam. METHODS AND FINDINGS: Fifteen measles IgM-positive patients with confusion or Glasgow Coma Scale (GCS) score below 13, and thirteen with uncomplicated measles were enrolled from 2008-2010. Standardized clinical exams were performed and blood collected for lymphocyte and measles- and auto-antibody analysis. The median age of AME patients was 21 years, similar to controls. Eleven reported recei..View full abstract
Awarded by South East Asian Infectious Diseases Clinical Research Network
Awarded by European Union
Awarded by Epilepsy Research UK
This work was funded by the South East Asian Infectious Diseases Clinical Research Network (Jl Diponegoro no 69, Jakarta, Indonesia, 10430) and the Wellcome Trust of Great Britain. AF was supported by the European Union FP7 project "European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE)" (no. 223498). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.