Diagnostic Accuracy of Microscopic Observation Drug Susceptibility (MODS) Assay for Pediatric Tuberculosis in Hanoi, Vietnam
Thi Tran Sinh, John Patrick Renschler, Thanh Le Hai, Thi Thu Dang Hang, Minh Dao Tuan, Nhat Pham An, Thanh Nguyen Liem, Van Nguyen Hung, Thi Thu Nguyen Thuy, Ngoc Le Sy, Annette Fox, Maxine Caws, Thi QuynhDo Nhu, Peter Horby, Heiman Wertheim
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
INTRODUCTION: Microscopic [corrected] Observation Drug Susceptibility (MODS) has been shown to be an effective and rapid technique for early diagnosis of tuberculosis (TB). Thus far only a limited number of studies evaluating MODS have been performed in children and in extra-pulmonary tuberculosis. This study aims to assess relative accuracy and time to positive culture of MODS for TB diagnosis in children admitted to a general pediatric hospital in Vietnam. METHODS/PRINCIPAL FINDINGS: Specimens from children with suspected TB were tested by smear, MODS and Lowenstein-Jensen agar (LJ). 1129 samples from 705 children were analyzed, including sputum (n=59), gastric aspirate (n=775), CSF (n=148..View full abstract
This work was funded by the Wellcome Trust Major Overseas Program in Vietnam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.