Journal article
Diagnostic Accuracy of Microscopic Observation Drug Susceptibility (MODS) Assay for Pediatric Tuberculosis in Hanoi, Vietnam
ST Tran, JP Renschler, HT Le, HTT Dang, TM Dao, AN Pham, LT Nguyen, H van Nguyen, T Thi Thu Nguyen, S Ngoc Le, A Fox, M Caws, ND Thi Quynh, P Horby, H Wertheim
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Introduction:icroscopic Observation Drug Susceptibility (MODS) has been shown to be an effective and rapid technique for early diagnosis of tuberculosis (TB). Thus far only a limited number of studies evaluating MODS have been performed in children and in extra-pulmonary tuberculosis. This study aims to assess relative accuracy and time to positive culture of MODS for TB diagnosis in children admitted to a general pediatric hospital in Vietnam.Methods/Principal Findings:Specimens from children with suspected TB were tested by smear, MODS and Lowenstein-Jensen agar (LJ). 1129 samples from 705 children were analyzed, including sputum (n = 59), gastric aspirate (n = 775), CSF (n = 148), pleural..
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Funding Acknowledgements
This work was funded by the Wellcome Trust Major Overseas Program in Vietnam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.