Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: Double blind randomised controlled trial

ER Sedyaningsih; MS Malik; V Setiawaty; T Trihono; E Burhan; TY Aditama; PZ Soepandi; LG Partakusuma; AP Sutiyoso; I Priatni; H Jusuf; EH Pranggono; AY Soeroto; D Setiabudi; DH Somasetia; S Sudarwati; TT Maskoen; Y Hartantri; I Parwati; S Giriputro; D Murniati; SM Sirait; T Soetanto; S Sulastri; R Agus; A Rusli; S Wiweka; S Wignall; K Baird; I Safika; C Sangsajja; W Manosuthi; P Sutha; C Chuchottaworn; P Sansayunh; K Bangpattanasiri; WRJ Taylor; K Stepniewska; C Fukuda; N Lindegardh; N White; N Day; T Chotpitayasunondh; P Suntarattiwong; U Chantbuddhiwet; S Netsawang; K Chokephaibulkit; N Vanprapar; W Prasitsuebsai; O Wittawatmongkol; T Anekthananon; W Ratanasuwan; Y Rongrungruang; P Puthavathana; PA Tambyah; YS Leo; D Fisher; L Chai; L Lee; R Lin; NNQ Minh; TH Khanh; LPK Thoa; LA Tuan; TTM Dung; LTT Ha; LM Qui; LQ Thinh; NNT Anh; TA Tuan; TH Nhien; BP Phuong; PT Qui; TC Thy; BX Vu; LBB Tinh; DT Thanh; VP Khanh; DC Viet; TT Thuy; VQ Bao; LNN Trung; HTK Thoa; TTN Anh; TTT Loan; TQ Huong; NTH Le; HL Viet; HM Tuan; NTT Ha; NVV Chau; NT Truong; LTT Thao; NT Phong; PTD Hien; PTH Men; CT Tam; TV Diet; NV Hao; N Van Kinh

Journal article

Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: Double blind randomised controlled trial

ER Sedyaningsih, MS Malik, V Setiawaty, T Trihono, E Burhan, TY Aditama, PZ Soepandi, LG Partakusuma, AP Sutiyoso, I Priatni, H Jusuf, EH Pranggono, AY Soeroto, D Setiabudi, DH Somasetia, S Sudarwati, TT Maskoen, Y Hartantri, I Parwati, S Giriputro Show all

BMJ Online | Published : 2013

DOI: 10.1136/bmj.f3039

Abstract

Objective: To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. Design: Double blind randomised trial. Setting: Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam. Participants: Patients aged ≥1 year admitted to hospital with confirmed severe influenza. Interventions: Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus standard dose (75 mg twice a day/paediatric equivalent). Main outcome measure: Viral status according to reverse transcriptase polymerase chain reaction (RT-PCR) for influenza RNA in nasal and throat swabs on day five. Results: Of 3..

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University of Melbourne Researchers

Annette Fox Author

Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

The study was conducted by the South East Asia Infectious Diseases Clinical Research Network (www.seaicrn.org/) and supported by the National Institute of Allergy and Infectious Diseases and the Wellcome Trust of Great Britain. The Singapore site was supported by the Singapore National Medical Research Council.