Influenza A H5N1 Clade 2.3.4 Virus with a Different Antiviral Susceptibility Profile Replaced Clade 1 Virus in Humans in Northern Vietnam
TQ Le Mai, FL Wertheim Heiman, D Nguyen Hien, Taylor Walter, VM Hoang Phuong, D Vuong Cuong, LK Nguyen Hang, H Nguyen Ha, Q Nguyen Thai, V Nguyen Trung, D Van Trang, T Ngoc Bich, N Bui Thinh, G Nguyen Binh, T Nguyen Liem, T Luong San, H Phan Phuc, V Pham Hung, Nguyen Tung, Fox Annette Show all
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008
BACKGROUND: Prior to 2007, highly pathogenic avian influenza (HPAI) H5N1 viruses isolated from poultry and humans in Vietnam were consistently reported to be clade 1 viruses, susceptible to oseltamivir but resistant to amantadine. Here we describe the re-emergence of human HPAI H5N1 virus infections in Vietnam in 2007 and the characteristics of the isolated viruses. METHODS AND FINDINGS: Respiratory specimens from patients suspected to be infected with avian influenza in 2007 were screened by influenza and H5 subtype specific polymerase chain reaction. Isolated H5N1 strains were further characterized by genome sequencing and drug susceptibility testing. Eleven poultry outbreak isolates from ..View full abstract
This work was supported by the Center for Disease Control, United States of America (NIHE - National Influenza Project) the South East Asian Influenza Clinical Research Network (SEAICRN), and the Wellcome Trust. The funding sources did not have a role in the design, data acquisition, analysis or writing of this report.