Incidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts
Philip C Hill, Dolly J Jackson-Sillah, Annette Fox, Roger H Brookes, Bouke C de Jong, Moses D Lugos, Ifedayo M Adetifa, Simon A Donkor, Alex M Aiken, Stephen R Howie, Tumani Corrah, Keith P McAdam, Richard A Adegbola
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2008
BACKGROUND: Studies of Tuberculosis (TB) case contacts are increasingly being utilised for understanding the relationship between M. tuberculosis and the human host and for assessing new interventions and diagnostic tests. We aimed to identify the incidence rate of new TB cases among TB contacts and to relate this to their initial Mantoux and ELISPOT test results. METHODS AND FINDINGS: After initial Mantoux and ELISPOT tests and exclusion of co-prevalent TB cases, we followed 2348 household contacts of sputum smear positive TB cases. We visited them at 3 months, 6 months, 12 months, 18 months and 24 months, and investigated those with symptoms consistent with TB. Those who were diagnosed sep..View full abstract
Awarded by Medical Research Council
This study was funded by the Medical Research Council (UK) and the European Commission. Neither funder had any role in conducting the study or preparing the manuscript.