Cascade screening based on genetic testing is cost-effective: Evidence for the implementation of models of care for familial hypercholesterolemia
Zanfina Ademi, Gerald F Watts, Jing Pang, Eric JG Sijbrands, Frank M van Bockxmeer, Peter O'Leary, Elizabeth Geelhoed, Danny Liew
Journal of Clinical Lipidology | ELSEVIER SCIENCE INC | Published : 2014
BACKGROUND: Familial hypercholesterolemia (FH) imposes significant burden of premature coronary heart disease (CHD). OBJECTIVE: This study aimed to determine the cost-effectiveness of FH detection based on genetic testing, supplemented with the measurement of plasma low-density lipoprotein cholesterol concentration, and treatment with statins. METHODS: A Markov model with a 10-year time horizon was constructed to simulate the onset of first-ever CHD and death in close relatives of probands with genetically confirmed FH. The model comprised of 3 health states: "alive without CHD," "alive with CHD," and "dead." Decision-analysis compared the clinical consequences and costs of cascade-screening..View full abstract
The cascade-screening program for FH in Western Australia was funded by the Australia Better Health Initiative and the Department of Health of Western Australia.