Human Pluripotent Stem Cell Strategies for Age-Related Macular Degeneration
Kathryn C Davidson, Robyn H Guymer, Martin F Pera, Alice Pebay
Optometry and Vision Science | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the Western world and is increasing exponentially as the population ages. Despite enormous worldwide efforts, the earliest pathogenic pathways involved in AMD are still not fully understood. It is essential to develop research tools for effective modeling of AMD pathogenesis and for subsequent drug discovery and cell or molecular therapies. This review will focus on the current progress in human pluripotent stem cells for understanding and treating AMD.
Awarded by NHMRC Project Grant
Awarded by NHMRC Centre for Clinical Research Excellence Award
This work was supported by a National Health and Medical Research Council (NHMRC) of Australia Fellowship (RHG), an NHMRC Career Development Award Fellowship (AP), an NHMRC Project Grant (#1059369), a National Stem Cell Foundation of Australia Research Support grant, an Ophthalmic Research Institute of Australia/RANZCO Eye Foundation Grant, and Stem Cells Australia, a Special Research Initiative in Stem Cell Science funded by the Australian Research Council. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian government and is supported by an NHMRC Centre for Clinical Research Excellence Award (#529923).