Journal article

Is Renal Function Associated with Early Age-Related Macular Degeneration?

Elaine W Chong, Robyn H Guymer, Ronald Klein, Barbara E Klein, Mary Frances Cotch, Jie Jin Wang, Michael G Shlipak, Tien Y Wong

Optometry and Vision Science | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

PURPOSE: Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD. METHODS: A population-based, cross-sectional analysis of persons aged 45 to 84 years was conducted with renal function measured using serum creatinine and cystatin C levels and the estimated glomerular filtration rate (eGFR) calculated. Age-related macular degeneration status was ascertained from retinal photographs. RESULTS: Of 5874 participants, 221 had early AMD. High serum cysta..

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