Is Renal Function Associated with Early Age-Related Macular Degeneration?
Elaine W Chong, Robyn H Guymer, Ronald Klein, Barbara E Klein, Mary Frances Cotch, Jie Jin Wang, Michael G Shlipak, Tien Y Wong
Optometry and Vision Science | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
PURPOSE: Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD. METHODS: A population-based, cross-sectional analysis of persons aged 45 to 84 years was conducted with renal function measured using serum creatinine and cystatin C levels and the estimated glomerular filtration rate (eGFR) calculated. Age-related macular degeneration status was ascertained from retinal photographs. RESULTS: Of 5874 participants, 221 had early AMD. High serum cysta..View full abstract
Awarded by National Heart, Lung, and Blood Institute
Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
Awarded by NATIONAL EYE INSTITUTE
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This study was supported by contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute.