Journal article

Cardiorespiratory responses to 6-minute walk test in interstitial lung disease: not always a submaximal test

Anne E Holland, Leona Dowman, Julio Fiore, Danny Brazzale, Catherine J Hill, Christine F McDonald



BACKGROUND: The 6-minute walk test (6 MWT) is used to measure exercise capacity and assess prognosis in interstitial lung disease (ILD). Although the 6 MWT is usually considered to be a test of submaximal exercise capacity in ILD, the physiological load imposed by this test is not well described and 6 MWT outcomes are poorly understood. This study aimed to compare cardiorespiratory responses to 6 MWT and cardiopulmonary exercise test (CPET) in people with ILD. METHODS: 47 participants with ILD (27 idiopathic pulmonary fibrosis (IPF), mean age 71 (SD 12) years, diffusing capacity for carbon monoxide (TLCO) 49(15) %predicted) undertook CPET and 6 MWT on the same day in random order. Oxygen upt..

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University of Melbourne Researchers


Funding Acknowledgements

This study was supported by the American Thoracic Society Foundation Research Program, the Pulmonary Fibrosis Foundation and La Trobe University. The funding bodies had no role in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.