Journal article

The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes

Wan Tinn Teh, Catharyn Stern, Sarat Chander, Martha Hickey

BioMed Research International | HINDAWI LTD | Published : 2014


Future fertility is of paramount importance to younger cancer survivors. Advances in assisted reproductive technology mean that young women treated with radiation involving the uterus may require clinical guidance regarding whether to attempt a pregnancy themselves. We performed a review of the literature regarding radiation involving uterus (total body irradiation (TBI) and pelvic radiation), fertility, and pregnancy outcomes to come up with a recommendation for our patients. Limited evidence suggests lower fecundity and an increased incidence of pregnancy complications after uterine radiation. Higher radiation doses and direct uterine radiation both significantly increase the risk of an ad..

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Funding Acknowledgements

The authors thank the Post Uterine Radiotherapy Pregnancy Research Group for their support with this paper. Members of the Post Uterine Radiotherapy Pregnancy Research Group: Peter Rogers, Jane Girling, Fiona Cullinane, Louise Kornman, Nicole Woodrow, Andrew Dobrotwir, Emma Pun, Sam Ngan, Julie Chu, Franca Agresta, and Jennifer Marino are also acknowledged.