Journal article

Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Boyd J Strauss, John M Wentworth, Jeffrey D Zajac, Mathis Grossmann

DIABETES CARE | AMER DIABETES ASSOC | Published : 2014

Abstract

OBJECTIVE: To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone. RESEARCH DESIGN AND METHODS: We conducted a randomized, double-blind, parallel, placebo-controlled trial in 88 men with T2D, aged 35-70 years with an HbA1c ≤8.5% (69 mmol/mol), and a total testosterone level, measured by immunoassay, of ≤12.0 nmol/L (346 ng/dL). Participants were randomly assigned to 40 weeks of intramuscular testosterone undecanoate (n = 45) or matching placebo (n = 43). All study subjects were included in the primary analysis. Seven men assigned to testosterone and six men receiving placebo did not complete the study. Main outcome mea..

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Grants

Awarded by National Health and Medical Research Council Postgraduate Fellowship


Awarded by Cardiovascular-Lipid Research Grant from Pfizer Australia


Awarded by National Health and Medical Research Council of Australia Career Development Fellowship


Funding Acknowledgements

Bayer Pharma AG (Berlin, Germany) provided testosterone and placebo. E.J.G. was supported by a National Health and Medical Research Council Postgraduate Fellowship (1018196), a Cardiovascular-Lipid Research Grant from Pfizer Australia (CR05.09), a Royal Australasian College of Physicians/Osteoporosis Australia Research Entry Grant, and a University of Melbourne Postgraduate Scholarship. M.G. was supported by a National Health and Medical Research Council of Australia Career Development Fellowship (1024139).