Journal article

Tonic arterial chemoreceptor activity contributes to cardiac sympathetic activation in mild ovine heart failure

Daniel T Xing, Clive N May, Lindsea C Booth, Rohit Ramchandra

Experimental Physiology | WILEY-BLACKWELL | Published : 2014

Abstract

Heart failure (HF) is associated with a large increase in cardiac sympathetic nerve activity (CSNA), which has detrimental effects on the heart and promotes arrhythmias and sudden death. There is increasing evidence that arterial chemoreceptor activation plays an important role in stimulating renal sympathetic nerve activity (RSNA) and muscle sympathetic nerve activity in HF. Given that sympathetic nerve activity to individual organs is differentially controlled, we investigated whether tonic arterial chemoreceptor activation contributes to the increased CSNA in HF. We recorded CSNA and RSNA in conscious normal sheep and in sheep with mild HF induced by rapid ventricular pacing (ejection fra..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council/National Heart Foundation Postdoctoral Fellowship


Awarded by National Health and Medical Research Council Research Fellowship


Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia Grant 628573 and the Victorian Government's Operational Infrastructure Support Program. R. Ramchandra was the recipient of National Health and Medical Research Council/National Heart Foundation Postdoctoral Fellowship 07M 3293, C. N. May was supported by a National Health and Medical Research Council Research Fellowship 566819, and L. C. Booth was the reciepient of a National Health and Medical Research Council Research Fellowship 1054619.