Journal article

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

Lindsay E Wu, Christopher C Meoli, Salvatore P Mangiafico, Daniel J Fazakerley, Victoria C Cogger, Mashani Mohamad, Himani Pant, Myung-Jin Kang, Elizabeth Powter, James G Burchfield, Chrysovalantou E Xirouchaki, A Stefanie Mikolaizak, Jacqueline Stoeckli, Ganesh Kolumam, Nicholas van Bruggen, Jennifer R Gamble, David G Le Couteur, Gregory J Cooney, Sofianos Andrikopoulos, David E James

Diabetes | AMER DIABETES ASSOC | Published : 2014

Abstract

The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic models provide conflicting evidence as to whether VEGF prevents or accelerates metabolic dysfunction during obesity. In the current study, we sought to identify the effects of VEGF-A neutralization on parameters of glucose metabolism and insulin action in a dietary mouse model of obesity. Within only 72 h of administration of the VEGF-A-neutralizing monoclonal antibody B.20-4.1, we observed almost complete reversal of high-fat diet-induced insuli..

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University of Melbourne Researchers