Journal article

Randomized Controlled Trial of Oxygen Saturation Targets in Very Preterm Infants: Two Year Outcomes

Brian A Darlow, Simone L Marschner, Mark Donoghoe, Malcolm R Battin, Roland S Broadbent, Mark J Elder, Michael P Hewson, Michael P Meyer, Alpana Ghadge, Patricia Graham, Nicolette J McNeill, Carl A Kuschel, William O Tarnow-Mordi



OBJECTIVE: To assess whether an oxygen saturation (Spo2) target of 85%-89% compared with 91%-95% reduced the incidence of the composite outcome of death or major disability at 2 years of age in infants born at <28 weeks' gestation. STUDY DESIGN: A total 340 infants were randomized to a lower or higher target from <24 hours of age until 36 weeks' gestational age. Blinding was achieved by targeting a displayed Spo2 of 88%-92% using a saturation monitor offset by ±3% within the range 85%-95%. True saturations were displayed outside this range. Follow-up at 2 years' corrected age was by pediatric examination and formal neurodevelopmental assessment. Major disability was gross motor disability, c..

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Awarded by New Zealand Health Research Council

Funding Acknowledgements

Funded by New Zealand Health Research Council (05/145) and the Child Health Research Foundation (Cure Kids). The authors declare no conflicts of interest.