Randomized Controlled Trial of Oxygen Saturation Targets in Very Preterm Infants: Two Year Outcomes
Brian A Darlow, Simone L Marschner, Mark Donoghoe, Malcolm R Battin, Roland S Broadbent, Mark J Elder, Michael P Hewson, Michael P Meyer, Alpana Ghadge, Patricia Graham, Nicolette J McNeill, Carl A Kuschel, William O Tarnow-Mordi
The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2014
OBJECTIVE: To assess whether an oxygen saturation (Spo2) target of 85%-89% compared with 91%-95% reduced the incidence of the composite outcome of death or major disability at 2 years of age in infants born at <28 weeks' gestation. STUDY DESIGN: A total 340 infants were randomized to a lower or higher target from <24 hours of age until 36 weeks' gestational age. Blinding was achieved by targeting a displayed Spo2 of 88%-92% using a saturation monitor offset by ±3% within the range 85%-95%. True saturations were displayed outside this range. Follow-up at 2 years' corrected age was by pediatric examination and formal neurodevelopmental assessment. Major disability was gross motor disability, c..View full abstract
Awarded by New Zealand Health Research Council
Funded by New Zealand Health Research Council (05/145) and the Child Health Research Foundation (Cure Kids). The authors declare no conflicts of interest.