Journal article

A multicentre feasibility study evaluating stress ulcer prophylaxis using hospital-based registry data

Edward Litton, Glenn M Eastwood, Rinaldo Bellomo, Richard Beasley, Michael J Bailey, Andrew B Forbes, David J Gattas, David V Pilcher, Steven AR Webb, Shay P McGuinness, Manoj K Saxena, Colin J McArthur, Paul J Young

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2014


BACKGROUND: It is unclear whether histamine-2 receptor blockers (H2RBs) or proton pump inhibitors (PPIs) are preferred for stress ulcer prophylaxis (SUP) in intensive care unit patients. Suitably powered comparative effectiveness trials are warranted. OBJECTIVE: To establish the feasibility of collecting process-of-care and outcome data relevant to a proposed interventional trial of SUP using existing databases. DESIGN, SETTING AND PARTICIPANTS: A retrospective cohort study conducted in seven Australia and New Zealand tertiary ICUs, including all patients ≥18 years admitted between 1 January 2011 and 31 December 2012. MAIN OUTCOME MEASURES: Doses of dispensed PPIs and H2RBs, upper gastrointe..

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University of Melbourne Researchers