Journal article
A multicentre feasibility study evaluating stress ulcer prophylaxis using hospital-based registry data
E Litton, GM Eastwood, R Bellomo, R Beasley, MJ Bailey, AB Forbes, DJ Gattas, DV Pilcher, SAR Webb, SP McGuinness, MK Saxena, CJ McArthur, PJ Young
Critical Care and Resuscitation | AUSTRALASIAN MED PUBL CO LTD | Published : 2014
Abstract
Background: It is unclear whether histamine-2 receptor blockers (H2RBs) or proton pump inhibitors (PPIs) are preferred for stress ulcer prophylaxis (SUP) in intensive care unit patients. Suitably powered comparative effectiveness trials are warranted. Objective: To establish the feasibility of collecting process-of-care and outcome data relevant to a proposed interventional trial of SUP using existing databases. Design, setting and participants: A retrospective cohort study conducted in seven Australia and New Zealand tertiary ICUs, including all patients ≥18 years admitted between 1 January 2011 and 31 December 2012. Main outcome measures: Doses of dispensed PPIs and H2RBs, upper gastrointe..
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