Journal article

IAP Family of Cell Death and Signaling Regulators

John Silke, Domagoj Vucic, A Ashkenazi (ed.), JA Wells (ed.), J Yuan (ed.)

Methods in enzymology | ELSEVIER ACADEMIC PRESS INC | Published : 2014

Abstract

Inhibitor of apoptosis (IAP) proteins interface with, and regulate a large number of, cell signaling pathways. If there is a common theme to these pathways, it is that they are involved in the development of the immune system, immune responses, and unsurprisingly, given their name, cell death. Beyond that it is difficult to discover an underlying logic because sometimes IAPs are required to inhibit or prevent signaling, whereas in other cases they are required for signaling to take place. In whatever role they play, they are recruited into signaling complexes and function as ubiquitin E3 ligases, via their RING domains. This review discusses IAP regulation of signaling pathways and focuses o..

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University of Melbourne Researchers