Journal article

No Evidence of Benefit from Antibiotic Lock Therapy in Pediatric Oncology Patients With Central Line-Related Bloodstream Infection: Results of a Retrospective Matched Cohort Study and Review of the Literature

Joshua Wolf, Kim J Allison, Li Tang, Yilun Sun, Randall T Hayden, Patricia M Flynn

Pediatric Blood & Cancer | WILEY-BLACKWELL | Published : 2014

Abstract

BACKGROUND: Long-term central venous catheters (CVCs) are essential to modern pediatric oncology practice, but central line-related bloodstream infection (CRBSI) is a frequent and important complication. CVC salvage is often attempted but treatment failure is common due to persistent infection, delayed catheter removal, or subsequent relapse of infection, which can be associated with significant morbidity and cost. Adjunctive antibiotic lock therapy (ALT) has been proposed to reduce the risk of treatment failure, but insufficient data are available to confirm efficacy of this intervention. PROCEDURE: We undertook a retrospective matched cohort study of ALT use for treatment of CRBSI in pedia..

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