Journal article

Association between Class III Obesity (BMI of 40-59 kg/m(2)) and Mortality: A Pooled Analysis of 20 Prospective Studies

Cari M Kitahara, Alan J Flint, Amy Berrington de Gonzalez, Leslie Bernstein, Michelle Brotzman, Robert J MacInnis, Steven C Moore, Kim Robien, Philip S Rosenberg, Pramil N Singh, Elisabete Weiderpass, Hans Olov Adami, Hoda Anton-Culver, Rachel Ballard-Barbash, Julie E Buring, D Michal Freedman, Gary E Fraser, Laura E Beane Freeman, Susan M Gapstur, John Michael Gaziano Show all

PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2014


BACKGROUND: The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity. METHODS AND FINDINGS: In a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex- and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year) and multivariable-adjusted hazard ratios for adults, age..

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Funding Acknowledgements

This work was supported in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health. Certain data were provided by the Vital Statistics Administration, Maryland Department of Health and Mental Hygiene, Baltimore, Maryland. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.